932-91 Ventricular Interdependence in Explanted Human Hearts

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Systolic ventricular interaction in normal and diseased explanted human hearts.

OBJECTIVE The purpose of this study was to quantify the magnitude of interaction between the right and left ventricles in conditions of heart failure. METHODS Human hearts were taken from transplant recipients diagnosed with diluted cardiomyopathy at the time of transplantation and were restored to beating condition with use of an isolated perfusion circuit. Left ventricular-right ventricular...

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AIMS Arrhythmogenic right ventricular Dysplasia/cardiomyopathy (ARVD/C) is an autosomal dominant inherited cardiomyopathy associated with ventricular arrhythmia, heart failure and sudden death. Genetic studies have demonstrated the central role of desmosomal proteins in this disease, where 50% of patients harbor a mutation in a desmosmal gene. However, clinical diagnosis of the disease remains ...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 1995

ISSN: 0735-1097

DOI: 10.1016/0735-1097(95)91952-t